PP405 & PowerExo: What’s Next in Hair Loss Treatment
This blog by Revital Trichology highlights both the future and present innovations in hair regrowth treatments. It introduces PP405, a breakthrough compound developed at UCLA, which promises effective hair restoration without hormonal side effects, unlike minoxidil or finasteride. Although PP405 is still in development and not yet available, the clinic offers an advanced PowerExo Exosome Therapy as an alternative.PowerExo, available in both topical and injectable forms, uses purified exosomes derived from stem cells to stimulate natural hair growth. The blog outlines how it works, who it is suitable for, its safety profile, and the impressive results already seen in patients with various forms of hair thinning and alopecia.Hair loss for some can be a lifelong concern. At Revital Trichology, we are committed to bringing the most advanced science-backed solutions to our patients in India. One of the most promising developments in recent times is a breakthrough molecule PP405, which is expected to transform hair regrowth treatments without the side effects associated with minoxidil or finasteride.While PP405 is still in development and expected to hit the market in the next five years, we’ve already had remarkable success with our in-house topical and injectable exosome-based therapy called PowerExo, a game-changing solution for those seeking safe, effective, and lasting hair regrowth.
What is PP405 and How Does It Work?
PP405, developed by researchers at UCLA, is a novel compound that stimulates hair growth without interacting with hormonal pathways. This means:- No risk of sexual side effects (commonly seen with finasteride)
- No rebound shedding or dependency
- No irritation or allergic reactions that are often linked to minoxidil
Mechanism of Action:
PP405 activates hair follicle stem cells and lengthens the anagen (growth) phase of hair follicles through a non-hormonal, cellular repair mechanism. This opens up the possibility for men and women of all ages and hormonal profiles to benefit from hair regrowth without risking systemic side effects.Unfortunately, PP405 is still under research and not yet available in the market.The Next Best Thing: PowerExo Exosome Therapy Available at Revital Trichology
While we wait for PP405 to become available, we’ve already seen outstanding results with our PowerExo line of exosome treatments both topical and injectable.Exosomes are extracellular signalling molecules extracted from various types of stem cells from blood, mesenchymal stem cells, adipose tissues, bone marrow, donor umbilical cord blood cells etc. They are completely devoid of cells.Why PowerExo is Different:
- Highly concentrated and purified exosomes
- Sourced from advanced stem cell processing labs
- Superior to most exosome products currently available in India
- Tested for purity, safety, and regenerative capacity
Types of PowerExo Treatments:
1. Topical Exosome Solution
- Applied daily on the scalp
- Suitable for men and women with early-to-moderate hair thinning
- Results visible in 4 to 6 months
- No pain, no downtime
- Can be combined with microneedling for better absorption
2. Injectable Exosome Therapy
- Delivered via meso injections or microneedling
- Option 1: Three sessions spaced 4–6 weeks apart
- Option 2: Single high-dose session for convenience
- Results seen in 3 to 6 months
- Ideal for individuals with diffuse thinning, stress-related hair loss, postpartum hair fall, or pattern baldness at an early stage
Who is a Candidate for Exosome Therapy?
- Men and women with early to moderate hair thinning
- People with androgenetic alopecia (male and female pattern hair loss)
- Individuals with stress-induced or post-COVID/post any infection hair loss
- Women with postpartum shedding
- Those who have not responded well to minoxidil or finasteride
- Patients looking for non-hormonal, side-effect-free treatments.
Safety and Side Effects
At Revital Trichology, patient safety is paramount. The PowerExo exosomes are lab-tested, sterile, and administered under medical supervision.Reported Side Effects:
- Mild redness or itching at injection site (subsides in 24–48 hours)
- No systemic or hormonal impact
- No long-term adverse effects reported